Chrysin Directing an Enhanced Solubility through the Formation of a Supramolecular Cyclodextrin-Calixarene Drug Delivery System: A Potential Strategy in Antifibrotic Diabetes Therapeutics

• Main Authors: Anca Hermenean (Author), Eleftheria Dossi (Author), Alex Hamilton (Author), Maria Consiglia Trotta (Author), Marina Russo (Author), Caterina Claudia Lepre (Author), Csilla Sajtos (Author), Ágnes Rusznyák (Author), Judit Váradi (Author), Ildikó Bácskay (Author), István Budai (Author), Michele D'Amico (Author), Ferenc Fenyvesi (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calixarene 0118 (OTX008) and chrysin (CHR) are promising molecules for the treatment of fibrosis and diabetes complications but require an effective delivery system to overcome their low solubility and bioavailability. Sulfobutylated β-cyclodextrin (SBECD) was evaluated for its ability to increase t...