A yeast-based screening assay identifies repurposed drugs that suppress mitochondrial fusion and mtDNA maintenance defects

• Main Authors: Thomas Delerue (Author), Déborah Tribouillard-Tanvier (Author), Marlène Daloyau (Author), Farnoosh Khosrobakhsh (Author), Laurent Jean Emorine (Author), Gaëlle Friocourt (Author), Pascale Belenguer (Author), Marc Blondel (Author), Laetitia Arnauné-Pelloquin (Author)
• Format: Book
• Published: The Company of Biologists, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondria continually move, fuse and divide, and these dynamics are essential for the proper function of the organelles. Indeed, the dynamic balance of fusion and fission of mitochondria determines their morphology and allows their immediate adaptation to energetic needs as well as preserving the...