Caspase-11 signaling promotes damage to hippocampal CA3 to enhance cognitive dysfunction in infection

• Main Authors: Ni Liang (Author), Yi Li (Author), Chuang Yuan (Author), Xiaoli Zhong (Author), Yanliang Yang (Author), Fang Liang (Author), Kai Zhao (Author), Fangfang Yuan (Author), Jian Shi (Author), Erhua Wang (Author), Yanjun Zhong (Author), Guixiang Tian (Author), Ben Lu (Author), Yiting Tang (Author)
• Format: Book
• Published: BMC, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cognitive dysfunction caused by infection frequently emerges as a complication in sepsis survivor patients. However, a comprehensive understanding of its pathogenesis remains elusive. Methods In our in vivo experiments, an animal model of endotoxemia was employed, utilizing the N...