Antibody-Based In Vivo Imaging of Central Nervous System Targets-Evaluation of a Pretargeting Approach Utilizing a TCO-Conjugated Brain Shuttle Antibody and Radiolabeled Tetrazines

Bioorthogonal pretargeted imaging using the inverse-electron-demand Diels-Alder (IEDDA) reaction between a tetrazine (Tz) and a <i>trans</i>-cyclooctene (TCO) represents an attractive strategy for molecular imaging via antibodies. The advantages of using a pretargeted imaging approach ar...

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Main Authors: Christoph Bredack (Author), Martin R. Edelmann (Author), Edilio Borroni (Author), Luca C. Gobbi (Author), Michael Honer (Author)
Format: Book
Published: MDPI AG, 2022-11-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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