Construction of a Dual-Fluorescence Reporter System to Monitor the Dynamic Progression of Pluripotent Cell Differentiation

• Main Authors: Wu-Sheng Sun (Author), Ju-Lan Chun (Author), Jeong-Tae Do (Author), Dong-Hwan Kim (Author), Jin-Seop Ahn (Author), Min-Kyu Kim (Author), In-Sul Hwang (Author), Dae-Jin Kwon (Author), Seong-Soo Hwang (Author), Jeong-Woong Lee (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oct4 is a crucial germ line-specific transcription factor expressed in different pluripotent cells and downregulated in the process of differentiation. There are two conserved enhancers, called the distal enhancer (DE) and proximal enhancer (PE), in the 5' upstream regulatory sequences (URSs) o...