Cholesterol absorption blocker ezetimibe prevents muscle wasting in severe dysferlin‐deficient and mdx mice

• Main Authors: Zoe White (Author), Marine Theret (Author), Nadia Milad (Author), Lin Wei Tung (Author), William Wei‐Han Chen (Author), Martin G. Sirois (Author), Fabio Rossi (Author), Pascal Bernatchez (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Muscular dystrophy (MD) causes muscle wasting and is often lethal in patients due to a lack of proven therapies. In contrast, mouse models of MD are notoriously mild. We have previously shown severe human‐like muscle pathology in mdx [Duchenne MD (DMD)] and dysferlin‐deficient li...