Targeting z-Crystallin by aspirin restores the sensitivity to cisplatin in resistant A2780 ovarian cancer cells

• Main Authors: Matteo Lulli (Author), Andrea Trabocchi (Author), Giandomenico Roviello (Author), Martina Catalano (Author), Laura Papucci (Author), Astrid Parenti (Author), Alice Molli (Author), Cristina Napoli (Author), Ida Landini (Author), Nicola Schiavone (Author), Andrea Lapucci (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ovarian cancer is the deadliest gynaecologic malignancies worldwide. Platinum based chemotherapy is the mainstay treatment for ovarian cancer; however, frequent recurrence and chemoresistance onset in patients with advanced diseases remain a therapeutic challenge. Although mechanisms underlying the...