Metallothionein synthesis increased by Ninjin-yoei-to, a Kampo medicine protects neuronal death and memory loss after exposure to amyloid β1-42

• Main Authors: Haruna Tamano (Author), Haruna Tokoro (Author), Daichi Murakami (Author), Rin Tsujimoto (Author), Yuka Nishijima (Author), Erina Tsuda (Author), Satoshi Watanabe (Author), Miki Suzuki (Author), Atsushi Takeda (Author)
• Format: Book
• Published: BMC, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background It is possible that increased synthesis of metallothioneins (MTs), Zn2+-binding proteins is linked with the protective effect of Ninjin-yoei-to (NYT) on Zn2+ toxicity ferried by amyloid β1-42 (Aβ1-42). Methods Judging from the biological half-life (18-20 h) of MTs, the effective...