Boost of solubility and supersaturation of celecoxib via synergistic interactions of methacrylic acid-ethyl acrylate copolymer (1:1) and hydroxypropyl cellulose in ternary amorphous solid dispersions

• Главные авторы: Florian Pöstges (Автор), Kevin Kayser (Автор), Edmont Stoyanov (Автор), Karl G. Wagner (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2022-12-01T00:00:00Z.
• Предметы: article
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A current trend in the development of amorphous solid dispersions (ASDs) is the combination of two polymers for synergistic enhancement in supersaturation of poorly soluble drugs. We investigated the supersaturation potential of celecoxib (CXB) using combinations of methacrylic acid-ethyl acrylate c...