Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human chagas disease.

• Main Authors: Ailin Lepletier (Author), Liliane de Almeida (Author), Leonardo Santos (Author), Luzia da Silva Sampaio (Author), Bruno Paredes (Author), Florencia Belén González (Author), Célio Geraldo Freire- (Author), Juan Beloscar (Author), Oscar Bottasso (Author), Marcelo Einicker-Lamas (Author), Ana Rosa Pérez (Author), Wilson Savino (Author), Alexandre Morrot (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The protozoan parasite Trypanosoma cruzi is able to target the thymus and induce alterations of the thymic microenvironmental and lymphoid compartments. Acute infection results in severe atrophy of the organ and early release of immature thymocytes into the periphery. To date, the pathophysiological...