Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancer

• Main Authors: Kang-Li Wang (Author), Tsung-Yu Yeh (Author), Pei-Chen Hsu (Author), Tzu-Hsuan Wong (Author), Jia-Rong Liu (Author), Ji-Wang Chern (Author), Miao-Hsia Lin (Author), Chao-Wu Yu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractA series of novel benzimidazole derivatives were designed and synthesised based on the structures of reported oral available ALK inhibitor and HDAC inhibitor, pracinostat. In enzymatic assays, compound 3b, containing a 2-acyliminobenzimidazole moiety and hydroxamic acid side chain, could inh...