Peripheral Antinociception by Carbamazepine in an Inflammatory Mechanical Hyperalgesia Model in the Rat: a New Target for Carbamazepine?
Abstract.: This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100 - 1000 nmol/paw) coadministrated with a proinflammatory compound, concanava...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Elsevier,
2006-01-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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| Summary: | Abstract.: This study investigated whether carbamazepine could produce local peripheral antinociception in a rat model of inflammatory mechanical hyperalgesia, and whether adenosine receptors are involved. Carbamazepine (100 - 1000 nmol/paw) coadministrated with a proinflammatory compound, concanavalin A, into the hind paw caused a significant dose- and time-dependent anti-hyperalgesia. Coadministration of caffeine (250 - 1000 nmol/paw), a non-selective adenosine-receptor antagonist, as well as DPCPX (10 - 30 nmol/paw), a selective adenosine A1-receptor antagonist, with carbamazepine, significantly depressed its antihyperalgesic effect. Drugs injected into the contralateral hind paw did not produce significant effects. These results suggest that carbamazepine produces local peripheral anti-hyperalgesia via peripheral adenosine A1 receptors. Keywords:: local carbamazepine, inflammatory mechanical hyperalgesia, adenosine A1 receptor |
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| Item Description: | 1347-8613 10.1254/jphs.SCE05003X |