Efficient CRISPR-Cas9-mediated mutagenesis in primary human B cells for identifying plasma cell regulators

• Main Authors: Tuan Anh Le (Author), Van Trung Chu (Author), Andreia C. Lino (Author), Eva Schrezenmeier (Author), Christopher Kressler (Author), Dania Hamo (Author), Klaus Rajewsky (Author), Thomas Dörner (Author), Van Duc Dang (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human B lymphocytes are attractive targets for immunotherapies in autoantibody-mediated diseases. Gene editing technologies could provide a powerful tool to determine gene regulatory networks regulating B cell differentiation into plasma cells, and identify novel therapeutic targets for prevention a...