Activation of Ceramidase and Ceramide Kinase by Vanadate via a Tyrosine Kinase-Mediated Pathway

• Main Authors: Eiko Tada (Author), Kaori Toyomura (Author), Hiroyuki Nakamura (Author), Hirotsune Sasaki (Author), Takeshi Saito (Author), Masayuki Kaneko (Author), Yasunobu Okuma (Author), Toshihiko Murayama (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Ceramide, a key molecule in the metabolism of sphingolipids, is converted by ceramidase to sphingosine, and phosphorylated by ceramide kinase to form ceramide-1-phosphate (C1P). In this study, we improved on a method of thin-layer chromatography using a fluorescent ceramide, 4-nitrobenzo-...