T-cell regulation in lepromatous leprosy.

• Main Authors: Kidist Bobosha (Author), Louis Wilson (Author), Krista E van Meijgaarden (Author), Yonas Bekele (Author), Martha Zewdie (Author), Jolien J van der Ploeg-van Schip (Author), Markos Abebe (Author), Jemal Hussein (Author), Saraswoti Khadge (Author), Kapil D Neupane (Author), Deanna A Hagge (Author), Ekaterina S Jordanova (Author), Abraham Aseffa (Author), Tom H M Ottenhoff (Author), Annemieke Geluk (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Regulatory T (Treg) cells are known for their role in maintaining self-tolerance and balancing immune reactions in autoimmune diseases and chronic infections. However, regulatory mechanisms can also lead to prolonged survival of pathogens in chronic infections like leprosy and tuberculosis (TB). Des...