Homozygous SPAG6 variants can induce nonsyndromic asthenoteratozoospermia with severe MMAF

• Main Authors: Chuan Xu (Author), Dongdong Tang (Author), Zhongmei Shao (Author), Hao Geng (Author), Yang Gao (Author), Kuokuo Li (Author), Qing Tan (Author), Guanxiong Wang (Author), Chao Wang (Author), Huan Wu (Author), Guanjian Li (Author), Mingrong Lv (Author), Xiaojin He (Author), Yunxia Cao (Author)
• Format: Book
• Published: BMC, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Multiple morphological abnormalities of the sperm flagella (MMAF) is a subtype of severe asthenoteratozoospermia with poorly understood genetic etiology. SPAG6 is a core axonemal component that plays a critical role in the formation of cilia and sperm flagella. Previous studies h...