Dehydroepiandrosterone suppresses human colorectal cancer progression through ER stress-mediated autophagy and apoptosis in a p53-independent manner

• Main Authors: Thi-Huong Nguyen (Author), Huey-Jiun Ko (Author), Po-Yu Tsai (Author), Tai-Shan Cheng (Author), Thu-Ha Tran (Author), Ly Hien Doan (Author), Michael Hsiao (Author), Peter Mu-Hsin Chang (Author), Hsiao-Sheng Liu (Author), Yi-Ren Hong (Author), Chi-Ying F. Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal cancer (CRC) is one of the primary contributors to cancer-related fatalities, with up to 80% of advanced CRC cases exhibiting mutations in the p53 gene. Unfortunately, the development of new compounds targeting mutant p53 is quite limited. The anticancer effects of Dehydroepiandrosterone...