Nicotinamide Supplementation Attenuates Renal Interstitial Fibrosis via Boosting the Activity of Sirtuins

• Main Authors: Xin Zhen (Author), Shaowu Zhang (Author), Feifei Xie (Author), Miaomiao Zhou (Author), Zheng Hu (Author), Fengxin Zhu (Author), Jing Nie (Author)
• Format: Book
• Published: Karger Publishers, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Progressive tubulointerstitial fibrosis (TIF) is the final common pathway leading to ESRD. There is an urgent need to develop effective approaches slowing the progression of TIF. Previous studies showed that systemic supplementation of nicotinamide (NAM) increases renal NAD+ and reverses...