The Alpha-Lipoic Acid Improves Survival and Prevents Irinotecan-Induced Inflammation and Intestinal Dysmotility in Mice

• Main Authors: Daniely V. S. Costa (Author), Deiziane V. S. Costa (Author), Caren N. S. Sousa (Author), Angeline M. H. P. Silva (Author), Ingridy S. Medeiros (Author), Dainesy S. Martins (Author), Conceição S. Martins (Author), Ana L. V. Pequeno (Author), Roberto C. P. Lima-Júnior (Author), Pedro M. G. Soares (Author), Silvânia M. M. Vasconcelos (Author), Gerly A. C. Brito (Author), Emmanuel P. Souza (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Irinotecan, an anticancer drug, induces diarrhea and intestinal inflammation, resulting in an increase in the cost of care and in treatment delays. In this study, we investigated whether alpha-lipoic acid (α-LA) could improve irinotecan-mediated intestinal inflammation, diarrhea and dysmotility. Int...