BIOLOGICAL ROLE OF ALDO-KETO REDUCTASES IN RETINOIC ACID BIOSYNTHESIS AND SIGNALING

• 主要な著者: F. Xavier eRuiz (著者), Sergio ePorté (著者), Xavier eParés (著者), Jaume eFarrés (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2012-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Several aldo-keto reductase (AKR) enzymes from subfamilies 1B and 1C show retinaldehyde reductase activity, having low Km and kcat values. Only AKR1B10 and 1B12, with all-trans-retinaldehyde, and AKR1C3, with 9-cis-retinaldehyde, display high catalytic efficiency. Major structural determinants for r...