Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity

• المؤلفون الرئيسيون: Qichao Yang (مؤلف), Xianbin Ma (مؤلف), Yao Xiao (مؤلف), Tian Zhang (مؤلف), Leilei Yang (مؤلف), Shaochen Yang (مؤلف), Mengyun Liang (مؤلف), Shuo Wang (مؤلف), Zhizhong Wu (مؤلف), Zhigang Xu (مؤلف), Zhijun Sun (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2022-07-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Aberrant activation of oncogenic signaling pathways in tumors can promote resistance to the antitumor immune response. However, single blockade of these pathways is usually ineffective because of the complex crosstalk and feedback among oncogenic signaling pathways. The enhanced toxicity of free sma...