Engineering prodrug nanomicelles as pyroptosis inducer for codelivery of PI3K/mTOR and CDK inhibitors to enhance antitumor immunity

• Main Authors: Qichao Yang (Author), Xianbin Ma (Author), Yao Xiao (Author), Tian Zhang (Author), Leilei Yang (Author), Shaochen Yang (Author), Mengyun Liang (Author), Shuo Wang (Author), Zhizhong Wu (Author), Zhigang Xu (Author), Zhijun Sun (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant activation of oncogenic signaling pathways in tumors can promote resistance to the antitumor immune response. However, single blockade of these pathways is usually ineffective because of the complex crosstalk and feedback among oncogenic signaling pathways. The enhanced toxicity of free sma...