Distribution of common BCR-ABL fusion transcripts and their impact on treatment response in Imatinib treated CML patients: A study from India

• Główni autorzy: Sudha Sazawal (Autor), Sunita Chhikara (Autor), Kanwaljeet Singh (Autor), Rekha Chaubey (Autor), Manoranjan Mahapatra (Autor), Tulika Seth (Autor), Renu Saxena (Autor)
• Format: Książka
• Wydane: Wolters Kluwer Medknow Publications, 2019-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Background: Philadelphia chromosome (Ph): Hallmark of CML is caused by reciprocal translocation between chromosomes 9 and 22 resulting in BCR-ABL fusion protein. Most commonly associated breakpoint with CML is M-bcr in exon 13 or exon 14, producing splice variant b2a2 or b3a2 respectively. The distr...