A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

• Main Authors: Emre E. Turer (Author), Miguel San Miguel (Author), Kuan-wen Wang (Author), William McAlpine (Author), Feiya Ou (Author), Xiaohong Li (Author), Miao Tang (Author), Zhao Zang (Author), Jianhui Wang (Author), Braden Hayse (Author), Bret Evers (Author), Xiaoming Zhan (Author), Jamie Russell (Author), Bruce Beutler (Author)
• Format: Book
• Published: The Company of Biologists, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) is a member of the basic helix-loop-helix/PER-ARNT-SIM (bHLH/PAS) transcription factor family. ARNT2 heterodimerizes with several members of the family, including single-minded homolog-1 (SIM1) and neuronal PAS domain protein 4 (NPAS4), primar...