Amyloid β directly interacts with NLRP3 to initiate inflammasome activation: identification of an intrinsic NLRP3 ligand in a cell-free system

• Main Authors: Ayaka Nakanishi (Author), Naoe Kaneko (Author), Hiroyuki Takeda (Author), Tatsuya Sawasaki (Author), Shinnosuke Morikawa (Author), Wei Zhou (Author), Mie Kurata (Author), Toshihiro Yamamoto (Author), Sheikh Mohammad Fazle Akbar (Author), Tamotsu Zako (Author), Junya Masumoto (Author)
• Format: Book
• Published: BMC, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Alzheimer's disease is a neurodegenerative disease characterized by the interstitial deposition of amyloid β (Aβ) plaque, which is thought to be related to chronic neuroinflammation. Aβ is known to make fibrils via oligomers from monomers. Aβ has been reported to activate th...