A quinazoline derivative suppresses B cell hyper-activation and ameliorates the severity of systemic lupus erythematosus in mice

Background: Aberrant autoreactive B cell responses contribute to the pathogenesis of systemic lupus erythematosus (SLE). Currently, there is no safe and effective drug for intervention of SLE. Quinazoline derivative (N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine, QNZ) is a NF-κB inhibitor and has p...

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Main Authors: Gan Zhang (Author), Fan Yang (Author), Juan Li (Author), Shan Chen (Author), Yuhang Kong (Author), Chunfen Mo (Author), Xiao Leng (Author), Yang Liu (Author), Ying Xu (Author), Yantang Wang (Author)
Format: Book
Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
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