A quinazoline derivative suppresses B cell hyper-activation and ameliorates the severity of systemic lupus erythematosus in mice

• Main Authors: Gan Zhang (Author), Fan Yang (Author), Juan Li (Author), Shan Chen (Author), Yuhang Kong (Author), Chunfen Mo (Author), Xiao Leng (Author), Yang Liu (Author), Ying Xu (Author), Yantang Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Aberrant autoreactive B cell responses contribute to the pathogenesis of systemic lupus erythematosus (SLE). Currently, there is no safe and effective drug for intervention of SLE. Quinazoline derivative (N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine, QNZ) is a NF-κB inhibitor and has p...