Role of synergy and immunostimulation in design of chemotherapy combinations: An analysis of doxorubicin and camptothecin

• Main Authors: Anusha Pusuluri (Author), Vinu Krishnan (Author), Debra Wu (Author), C. Wyatt Shields IV (Author), Li W. Wang (Author), Samir Mitragotri (Author)
• Format: Book
• Published: Wiley, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Combination chemotherapy is often employed to improve therapeutic efficacies of drugs. However, traditional combination regimens often utilize drugs at or near‐their maximum tolerated doses (MTDs), elevating the risk of dose‐related toxicity and impeding their clinical success. Further, hig...