Development of Hif1α pharmacogenomic mutation models to study individual variations in drug action for tumor hypoxia: An in silico approach

• Κύριοι συγγραφείς: Vaisali Balasubramaniam (Συγγραφέας), P K Krishnan Namboori (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Wolters Kluwer Medknow Publications, 2021-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Objective: Tumor hypoxia, a predominant feature of solid tumor produces drug resistance that significantly impacts a patient's clinical outcomes. Hypoxia-inducible factor 1-alpha (HIF1α) is the major mutation involved in establishing the microenvironment. As a consequence of its involvement in...