Akt Is a Molecular Target for Signal Transduction Therapy in Brain Ischemic Insult

• 主要な著者: Kohji Fukunaga (著者), Takayuki Kawano (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2003-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Growth factors including insulin-like growth factor-1 (IGF-1) promote cell survival in ischemic brain injury. Stimulation of IGF-1 receptor coupled with tyrosine kinase activates phosphatidylinositol 3-kinase and subsequently, protein kinase B (Akt) in hippocampal neurons. Here we introduce a new ap...