Declining antibody levels to Trypanosoma cruzi correlate with polymerase chain reaction positivity and electrocardiographic changes in a retrospective cohort of untreated Brazilian blood donors.

• Main Authors: Lewis F Buss (Author), Léa Campos de Oliveira-da Silva (Author), Carlos H V Moreira (Author), Erika R Manuli (Author), Flavia C Sales (Author), Ingra Morales (Author), Clara Di Germanio (Author), Cesar de Almeida-Neto (Author), Sonia Bakkour (Author), Paul Constable (Author), Marcelo M Pinto-Filho (Author), Antonio L Ribeiro (Author), Michael Busch (Author), Ester C Sabino (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Although infection with Trypanosoma cruzi is thought to be lifelong, less than half of those infected develop cardiomyopathy, suggesting greater parasite control or even clearance. Antibody levels appear to correlate with T. cruzi (antigen) load. We test the associatio...