Evaluation of Brain Targeting and Antipsychotic Activity of Nasally Administrated Ziprasidone Lipid-Polymer Hybrid Nanocarriers

• Main Authors: Hadel A. Abo El-Enin (Author), Alaa S. Tulbah (Author), Hany W. Darwish (Author), Rania Salama (Author), Ibrahim A. Naguib (Author), Heba A. Yassin (Author), Hend Mohamed Abdel-Bar (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The feasibility of using lipid-polymer hybrid (LPH) nanocarriers as a potential platform for the intranasal delivery of ziprasidone (ZP), a second-generation antipsychotic, was explored. Different ZP-loaded LPH composed of a PLGA core and cholesterol-lecithin lipid coat were prepared using a single...