In Vitro Stability and Pharmacokinetic Study of Pedunculoside and Its Beta-CD Polymer Inclusion Complex

• Main Authors: Liang Wu (Author), Danfeng Li (Author), Peijing Wang (Author), Linling Dong (Author), Wang Zhang (Author), Jianjun Xu (Author), Xiaoliang Jin (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pedunculoside, a triterpene saponin derived from various <i>Ilex</i> species, holds potential as a treatment for cardiovascular diseases. However, its clinical application is hindered by poor bioavailability, rapid elimination, and extensive intestinal metabolism to rotundic acid. To add...