Predicting Hydroxychloroquine Clearance in Healthy and Diseased Populations Using a Physiologically Based Pharmacokinetic Approach

• Main Authors: Faleh Alqahtani (Author), Ali Mohammed Asiri (Author), Ammara Zamir (Author), Muhammad Fawad Rasool (Author), Amer S. Alali (Author), Sary Alsanea (Author), Ismail A. Walbi (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hydroxychloroquine (HCQ), a congener of chloroquine, is widely used in prophylaxis and the treatment of malaria, and also as a cure for rheumatoid arthritis, systemic lupus erythematosus, and various other diseases. Physiologically based pharmacokinetic modeling (PBPK) has attracted great interest i...