BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy

• मुख्य लेखकों: Tina Zimmermann (लेखक), Leo Thomas (लेखक), Tamara Baader-Pagler (लेखक), Peter Haebel (लेखक), Eric Simon (लेखक), Wolfgang Reindl (लेखक), Besnik Bajrami (लेखक), Wolfgang Rist (लेखक), Ingo Uphues (लेखक), Daniel J. Drucker (लेखक), Holger Klein (लेखक), Rakesh Santhanam (लेखक), Dieter Hamprecht (लेखक), Heike Neubauer (लेखक), Robert Augustin (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Obesity and its associated comorbidities represent a global health challenge with a need for well-tolerated, effective, and mechanistically diverse pharmaceutical interventions. Oxyntomodulin is a gut peptide that activates the glucagon receptor (GCGR) and glucagon-like peptide-1 receptor...