BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy

• Main Authors: Tina Zimmermann (Author), Leo Thomas (Author), Tamara Baader-Pagler (Author), Peter Haebel (Author), Eric Simon (Author), Wolfgang Reindl (Author), Besnik Bajrami (Author), Wolfgang Rist (Author), Ingo Uphues (Author), Daniel J. Drucker (Author), Holger Klein (Author), Rakesh Santhanam (Author), Dieter Hamprecht (Author), Heike Neubauer (Author), Robert Augustin (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity and its associated comorbidities represent a global health challenge with a need for well-tolerated, effective, and mechanistically diverse pharmaceutical interventions. Oxyntomodulin is a gut peptide that activates the glucagon receptor (GCGR) and glucagon-like peptide-1 receptor...