BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy

Objective: Obesity and its associated comorbidities represent a global health challenge with a need for well-tolerated, effective, and mechanistically diverse pharmaceutical interventions. Oxyntomodulin is a gut peptide that activates the glucagon receptor (GCGR) and glucagon-like peptide-1 receptor...

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Main Authors: Tina Zimmermann (Author), Leo Thomas (Author), Tamara Baader-Pagler (Author), Peter Haebel (Author), Eric Simon (Author), Wolfgang Reindl (Author), Besnik Bajrami (Author), Wolfgang Rist (Author), Ingo Uphues (Author), Daniel J. Drucker (Author), Holger Klein (Author), Rakesh Santhanam (Author), Dieter Hamprecht (Author), Heike Neubauer (Author), Robert Augustin (Author)
Formato: Livro
Publicado em: Elsevier, 2022-12-01T00:00:00Z.
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