Marine fungus Aspergillus c1. sp metabolite activates the HSF1/PGC-1α axis, inducing a thermogenic program for treating obesity

• Main Authors: Yong Rao (Author), Rui Su (Author), Chenyan Wu (Author), Guanyu Yang (Author), Renquan Fu (Author), Junjie Wu (Author), Jinqiang Liang (Author), Jin Liu (Author), Zhongping Jiang (Author), Congjun Xu (Author), Ling Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and aims: Obesity is one of the most prevalent diseases worldwide with less ideal approved agents in clinic. Activating the HSF1/PGC-1α axis in adipose tissues has been reported to induce thermogenesis in mice, which presents a promising therapeutic avenue for obesity treatment. The prese...