Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein-cytochrome P450 3A4 dual substrates
Abstract Rifampicin induces both P‐glycoprotein (P‐gp) and cytochrome P450 3A4 (CYP3A4) through regulating common nuclear receptors (e.g., pregnane X receptor). The interplay of P‐gp and CYP3A4 has emerged to be an important factor in clinical drug-drug interactions (DDIs) with P‐gp-CYP3A4 dual subs...
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| Main Authors: | , , , , |
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| Format: | Book |
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Wiley,
2021-12-01T00:00:00Z.
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