Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein-cytochrome P450 3A4 dual substrates

• Ngā kaituhi matua: Xian Pan (Author), Shinji Yamazaki (Author), Sibylle Neuhoff (Author), Mian Zhang (Author), Venkatesh Pilla Reddy (Author)
• Hōputu: Pukapuka
• I whakaputaina: Wiley, 2021-12-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Abstract Rifampicin induces both P‐glycoprotein (P‐gp) and cytochrome P450 3A4 (CYP3A4) through regulating common nuclear receptors (e.g., pregnane X receptor). The interplay of P‐gp and CYP3A4 has emerged to be an important factor in clinical drug-drug interactions (DDIs) with P‐gp-CYP3A4 dual subs...