A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer

Modulating Tankyrases (TNKS), interactions with USP25 to promote TNKS degradation, rather than inhibiting their enzymatic activities, is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway. Here, we identified UAT-B, a novel neoantimycin analog isolated from Streptomyce...

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Main Authors: Hongrui Zhu (Author), Yamin Gao (Author), Liyun Liu (Author), Mengyu Tao (Author), Xiao Lin (Author), Yijia Cheng (Author), Yaoyao Shen (Author), Haitao Xue (Author), Li Guan (Author), Huimin Zhao (Author), Li Liu (Author), Shuping Wang (Author), Fan Yang (Author), Yongjun Zhou (Author), Hongze Liao (Author), Fan Sun (Author), Houwen Lin (Author)
Format: Book
Published: Elsevier, 2024-01-01T00:00:00Z.
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