A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer

• मुख्य लेखकों: Hongrui Zhu (लेखक), Yamin Gao (लेखक), Liyun Liu (लेखक), Mengyu Tao (लेखक), Xiao Lin (लेखक), Yijia Cheng (लेखक), Yaoyao Shen (लेखक), Haitao Xue (लेखक), Li Guan (लेखक), Huimin Zhao (लेखक), Li Liu (लेखक), Shuping Wang (लेखक), Fan Yang (लेखक), Yongjun Zhou (लेखक), Hongze Liao (लेखक), Fan Sun (लेखक), Houwen Lin (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2024-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Modulating Tankyrases (TNKS), interactions with USP25 to promote TNKS degradation, rather than inhibiting their enzymatic activities, is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway. Here, we identified UAT-B, a novel neoantimycin analog isolated from Streptomyce...