Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model

• मुख्य लेखकों: Kazuya Kabei (लेखक), Yu Tateishi (लेखक), Masayuki Shiota (लेखक), Mayuko Osada-Oka (लेखक), Shunji Nishide (लेखक), Junji Uchida (लेखक), Tatsuya Nakatani (लेखक), Shinji Matsunaga (लेखक), Takehiro Yamaguchi (लेखक), Shuhei Tomita (लेखक), Katsuyuki Miura (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Orally active hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors that stabilize HIF protein and stimulate the production of erythropoietin have been approved to treat renal anemia. Our previous report suggested that HIF-1α dependent fibrogenic mechanisms are operating at the early onset of...