A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)

• Asıl Yazarlar: Brandi L. Carofino (Yazar), Bernard Ayanga (Yazar), Monica J. Justice (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: The Company of Biologists, 2013-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

SUMMARY PRDM14 functions in embryonic stem cell (ESC) maintenance to promote the expression of pluripotency-associated genes while suppressing differentiation genes. Expression of PRDM14 is tightly regulated and typically limited to ESCs and primordial germ cells; however, aberrant expression is ass...