Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma

• Автори: Biao Wang (Автор), Fu Peng (Автор), Wei Huang (Автор), Jin Zhou (Автор), Nan Zhang (Автор), Jia Sheng (Автор), Phensinee Haruehanroengra (Автор), Gu He (Автор), Bo Han (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2020-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Simultaneous inhibition of MDM2 and CDK4 may be an effective treatment against glioblastoma. A collection of chiral spirocyclic tetrahydronaphthalene (THN)-oxindole hybrids for this purpose have been developed. Appropriate stereochemistry in THN-fused spirooxindole compounds is key to their inhibito...