Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model.

• Main Authors: Hanna K De Jong (Author), Ahmed Achouiti (Author), Gavin C K W Koh (Author), Christopher M Parry (Author), Stephen Baker (Author), Mohammed Abul Faiz (Author), Jaap T van Dissel (Author), Albert M Vollaard (Author), Ester M M van Leeuwen (Author), Joris J T H Roelofs (Author), Alex F de Vos (Author), Johannes Roth (Author), Tom van der Poll (Author), Thomas Vogl (Author), Willem Joost Wiersinga (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide. S100A8 (MRP8) and S100A9 (MRP14) form bioactive antimicrobial heterodimers (calprotectin) that can activate Toll-like receptor 4,...