Exploring the druggability of the binding site of aurovertin, an exogenous allosteric inhibitor of FOF1-ATP synthase

• Main Authors: Luis Fernando Cofas-Vargas (Author), Paola Mendoza-Espinosa (Author), Luis Pablo Avila-Barrientos (Author), Diego Prada-Gracia (Author), Héctor Riveros-Rosas (Author), Enrique García-Hernández (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In addition to playing a central role in the mitochondria as the main producer of ATP, FOF1-ATP synthase performs diverse key regulatory functions in the cell membrane. Its malfunction has been linked to a growing number of human diseases, including hypertension, atherosclerosis, cancer, and some ne...