Exploring the druggability of the binding site of aurovertin, an exogenous allosteric inhibitor of FOF1-ATP synthase

• मुख्य लेखकों: Luis Fernando Cofas-Vargas (लेखक), Paola Mendoza-Espinosa (लेखक), Luis Pablo Avila-Barrientos (लेखक), Diego Prada-Gracia (लेखक), Héctor Riveros-Rosas (लेखक), Enrique García-Hernández (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

In addition to playing a central role in the mitochondria as the main producer of ATP, FOF1-ATP synthase performs diverse key regulatory functions in the cell membrane. Its malfunction has been linked to a growing number of human diseases, including hypertension, atherosclerosis, cancer, and some ne...