The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity

• Main Authors: Zhuo-Qing Li (Author), Li-Long Jiang (Author), Dong-Sheng Zhao (Author), Jing Zhou (Author), Ling-Li Wang (Author), Zi-Tian Wu (Author), Xian Zheng (Author), Zi-Qi Shi (Author), Ping Li (Author), Hui-Jun Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dictamni Cortex (DC) has been reported to be associated with acute hepatitis in clinic and may lead to a selective sub-chronic hepatotoxicity in rats. Nevertheless, the potent toxic ingredient and the underlying mechanism remain unknown. Dictamnine (DTN), the main alkaloid from DC, possesses a furan...