The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity
Dictamni Cortex (DC) has been reported to be associated with acute hepatitis in clinic and may lead to a selective sub-chronic hepatotoxicity in rats. Nevertheless, the potent toxic ingredient and the underlying mechanism remain unknown. Dictamnine (DTN), the main alkaloid from DC, possesses a furan...
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Frontiers Media S.A.,
2018-09-01T00:00:00Z.
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