The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity

• Asıl Yazarlar: Zhuo-Qing Li (Yazar), Li-Long Jiang (Yazar), Dong-Sheng Zhao (Yazar), Jing Zhou (Yazar), Ling-Li Wang (Yazar), Zi-Tian Wu (Yazar), Xian Zheng (Yazar), Zi-Qi Shi (Yazar), Ping Li (Yazar), Hui-Jun Li (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Dictamni Cortex (DC) has been reported to be associated with acute hepatitis in clinic and may lead to a selective sub-chronic hepatotoxicity in rats. Nevertheless, the potent toxic ingredient and the underlying mechanism remain unknown. Dictamnine (DTN), the main alkaloid from DC, possesses a furan...