Global IP6K1 deletion enhances temperature modulated energy expenditure which reduces carbohydrate and fat induced weight gain

Objective: IP6 kinases (IP6Ks) regulate cell metabolism and survival. Mice with global (IP6K1-KO) or adipocyte-specific (AdKO) deletion of IP6K1 are protected from diet induced obesity (DIO) at ambient (23 °C) temperature. AdKO mice are lean primarily due to increased AMPK mediated thermogenic energ...

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Main Authors: Qingzhang Zhu (Author), Sarbani Ghoshal (Author), Richa Tyagi (Author), Anutosh Chakraborty (Author)
Format: Book
Published: Elsevier, 2017-01-01T00:00:00Z.
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3rd Floor Main Library

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