Optimization of a Quantitative Anti-Drug Antibodies against Infliximab Assay with the Liquid Chromatography-Tandem Mass Spectrometry: A Method Validation Study and Future Perspectives

• Main Authors: Erin H. Smeijsters (Author), Kim C. M. van der Elst (Author), Amy Visch (Author), Camiel Göbel (Author), Floris C. Loeff (Author), Theo Rispens (Author), Alwin D. R. Huitema (Author), Matthijs van Luin (Author), Mohsin El Amrani (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Monoclonal antibodies (mAbs), such as infliximab, are important treatment options for different diseases. Immunogenicity is a major risk, resulting in anti-drug antibodies (ADAs), being associated with adverse events and loss of response, influencing long-term outcomes. The development of ADAs again...