Induction of CD8+ immune memory and enhanced inflammation in a skin inflammation model through pre‐immunization with inactivated pathogens

• Main Authors: Caroline Falkenberg (Author), Christina Bartholdy (Author), Janne Koch (Author), Martin Fitzner Toft (Author), Søren Skov (Author), Camilla Hartmann Friis Hansen (Author), Axel Kornerup Hansen (Author)
• Format: Book
• Published: Wiley, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Laboratory mice live in specific pathogen‐free (SPF) conditions, resulting in an immature immune system comparable to that of newborns rather than adult humans or mice from pet shops. This condition may compromise their translational value. Reintroducing pathogens would lead to the uncontro...