Sustained increased CaMKII phosphorylation is involved in the impaired regression of isoproterenol-induced cardiac hypertrophy in rats

• Main Authors: Jingyuan Li (Author), Qinghua Gao (Author), Siqi Wang (Author), Ze Kang (Author), Zhuo Li (Author), Shuai Lei (Author), Xuefei Sun (Author), Meimi Zhao (Author), Xiye Chen (Author), Guangyu Jiao (Author), Huiyuan Hu (Author), Liying Hao (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To understand the mechanism underlying the regression of cardiac hypertrophy, we investigated the pathological changes after isoproterenol (ISO) withdrawal in ISO-induced cardiomyopathy models in rats and neonatal cardiomyocytes. Cardiac hypertrophy was induced in rats by two weeks of ISO administra...