Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy

• Main Authors: Fernando Alvarez-Rivera (Author), Ana Rey-Rico (Author), Jagadeesh K Venkatesan (Author), Luis Diaz-Gomez (Author), Magali Cucchiarini (Author), Angel Concheiro (Author), Carmen Alvarez-Lorenzo (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As an alternative to eye drops and ocular injections for gene therapy, the aim of this work was to design for the first time hydrogel contact lenses that can act as platforms for the controlled delivery of viral vectors (recombinant adeno-associated virus, rAAV) to the eye in an effective way with i...