Suppression of IGF1R in Melanoma Cells by an Adenovirus-Mediated One-Step Knockdown System

• Main Authors: Haoran Xin (Author), Mingxing Lei (Author), Zhihui Zhang (Author), Jie Li (Author), Hao Zhang (Author), Xinwei Luo (Author), Aoyun Wang (Author), Fang Deng (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abnormal activation of the IGF1R signaling pathway accelerates melanoma development and metastases. RNAi systems with complex cloning procedures and unsatisfactory efficiency in suppressing gene expression have become the technical difficulties that hinder their utility when studying gene knockdown....