Design and optimization of topical terbinafine hydrochloride nanosponges: Application of full factorial design, in vitro and in vivo evaluation

• Main Authors: Reham I Amer (Author), Ghada H El-Osaily (Author), Sameh S Gad (Author)
• Format: Knjiga
• Izdano: Wolters Kluwer Medknow Publications, 2020-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Terbinafine hydrochloride (THCl) has a broad-spectrum antifungal activity. THCl has oral bioavailability 40%, which increases dosing frequency of the drug, thus leads to some systemic side effects. Sustained release THCl nanosponges hydrogel was fabricated to deliver the drug topically. Pure THCl (d...